The “Leaky Gut”: Tight Junctions but Loose Associations?
نویسندگان
چکیده
منابع مشابه
Tight Junctions
Epithelial cells cover the body (e.g. skin), cavities (e.g. stomach, uterus, bladder) and ducts (e.g. renal tubules, intestine) of multicellular organisms, and thus constitute the frontier between the individual and the external milieu. In areas that withstand strong mechanical or chemical stress (e.g. skin, esophagus, cornea, vagina) epithelia are stratified, whereas in the rest of the body, t...
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Tight junctions are the most apical intercellular junctions of epithelial and endothelial cells and create a regulatable semipermeable diffusion barrier between individual cells. On a cellular level, they form an intramembrane diffusion fence that restricts the intermixing of apical and basolateral membrane components. In addition to these well defined functions, more recent evidence suggests t...
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The chances of being diagnosed with Leaky Gut Syndrome are pretty remote. It does not even occur to many doctors to check for the condition. A further complication is that gut distress often manifests as disease in other parts of the body. Leaky Gut Syndrome is one of the most misunderstood concepts in modern medicine. This condition is associated with an abnormal increase in the permeability o...
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Autoimmune diseases are characterized by tissue damage and loss of function due to an immune response that is directed against specific organs. This review is focused on the role of impaired intestinal barrier function on autoimmune pathogenesis. Together with the gut-associated lymphoid tissue and the neuroendocrine network, the intestinal epithelial barrier, with its intercellular tight junct...
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ژورنال
عنوان ژورنال: Digestive Diseases and Sciences
سال: 2019
ISSN: 0163-2116,1573-2568
DOI: 10.1007/s10620-019-05777-2